Explanation:

Despite: Never takes 'of'. (Correct: "Despite the rain").
In spite of: Always takes 'of'. (Correct: "In spite of the rain").
Although: Must be followed by a Clause (Subject + Verb). "Although it was raining..." (Not "Although the rain").

Therefore, Option C is the only correct structure.

Detailed Topic Insight (Despite vs. Although):
Both show contrast, but the grammar differs.

Connector + Noun Phrase: Despite, In spite of, Due to. ("Despite the noise").
Connector + Clause: Although, Even though, Because. ("Although it was noisy").
Common Error: "Despite of" is a major Indian English error. It is either "Despite" or "In spite of".

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